Deletion of Integrin-Linked Kinase from Skeletal Muscles of Mice Resembles Muscular Dystrophy Due to 7 1-Integrin Deficiency
نویسندگان
چکیده
Ania L. Gheyara,* Ainara Vallejo-Illarramendi, Keling Zang, Lin Mei, Rene St.-Arnaud, Shoukat Dedhar, and Louis F. Reichardt From the Departments of Pathology* and Physiology, University of California, San Francisco, California; the Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, Georgia; the Shriners Hospital and McGill University, Montreal, Quebec, Canada; and the Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
منابع مشابه
Enhanced Expression of the α7β1 Integrin Reduces Muscular Dystrophy and Restores Viability in Dystrophic Mice
Muscle fibers attach to laminin in the basal lamina using two distinct mechanisms: the dystrophin glycoprotein complex and the alpha 7 beta 1 integrin. Defects in these linkage systems result in Duchenne muscular dystrophy (DMD), alpha 2 laminin congenital muscular dystrophy, sarcoglycan-related muscular dystrophy, and alpha 7 integrin congenital muscular dystrophy. Therefore, the molecular con...
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Muscle fibers attach to laminin in the basal lamina using two distinct mechanisms: the dystrophin glycoprotein complex and the a 7 b 1 integrin. Defects in these linkage systems result in Duchenne muscular dystrophy (DMD), a 2 laminin congenital muscular dystrophy, sarcoglycan-related muscular dystrophy, and a 7 integrin congenital muscular dystrophy. Therefore, the molecular continuity between...
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Skeletal muscle expresses high levels of integrin-linked kinase (ILK), predominantly at myotendinous junctions (MTJs) and costameres. ILK binds the cytoplasmic domain of beta1 integrin and mediates phosphorylation of protein kinase B (PKB)/Akt, which in turn plays a central role during skeletal muscle regeneration. We show that mice with a skeletal muscle-restricted deletion of ILK develop a mi...
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Introduction: Skeletal muscle is a flexible and ever changing tissue and the role of costameric proteins in its response to different stimuli is not well defined. The aim of this study was to investigate the effect of progressive resistance exercise on β1 integrin and vinculin proteins in fast and slow twitch skeletal muscles of male rats. Methods: Twelve male Wistar rats (weight: 298±5.2 gr...
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